Sargon II (reigned 721-705 B.C.) was a ruler of Assyria, also known as Sharrukin II or Sharru-kin II. His palace was located at Dur Sharrukin, now known as Khorsabad.

Under the rule of Sargon the Assyrians completed the defeat of the Kingdom of Israel, capturing Samaria after a siege of three years and dispersing the inhabitants. This became the basis of the legend of the Lost Ten Tribes.